I used Squarespace for a photography portfolio. It was simple to get started and the site was easy to use for the most part.
I ran into a few problems when trying to get photos lined up in columns -- it wasn't clear the best way to do it. Photos would resize weird and take up more space than they should have. I eventually figured out that if I remove them and add them back they behave better.
I love that I don't need to know fancy HTML or CSS or whatever to build a professional looking site.
